专题羟基脲治疗复发性脑膜瘤

羟基脲治疗复发性脑膜瘤

目前还没有针对恶性脑膜瘤及复发性脑膜瘤的有效化疗方案。已有运用蒽环类、顺铂和CPT-11的治疗报道，但都没有观察到确定的疗效。近年来有数个前期临床研究显示，羟基脲在治疗复发性脑膜瘤时能够延缓疾病进展，使患者获益。今天山东省脑瘤带大家一块了解一下羟基脲治疗脑膜瘤的新进展：

Meningiomasrepresent18-20%ofallintracranialtumorsandhavea20-50%10-yearrecurrencerate,despiteaggressivesurgeryandirradiation.Hydroxyurea,aninhibitorofribonucleotidereductase,isknowntoinhibitmeningiomacellsbyinductionofapoptosis.Wereportthelong-termfollow-upresultofhydroxyureatherapyinthepatientswithrecurrentmeningiomas.

ThirteenpatientswithrecurrentWHOgradeIorIImeningiomaweretreatedwithhydroxyurea(mg/m2/dayorallydividedtwiceperday)fromJunetoFebruary.Ninefemaleand4male,ranginginagefrom32to83years(medianage61.7years),wereincluded.Follow-upassessmentincludedphysicalexamination,







































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